Phoenix, Arizona, suburban mom Allison DuBois (Patricia Arquette) is a strong-willed young mother of three, a devoted wife, and law student who begins to suspect that she can talk to dead people, see the future in her dreams, and read people's thoughts. Fearing for her mental health, she turns for support to her husband Joe (Jake Weber, U-571), an aerospace engineer, who slowly comes to believe that what his wife is telling him just might be true upon discovering that she dreams of a murder in Texas. The real challenge is convincing her boss, D.A. Devalos (Miguel Sandoval) -- and the other doubters in the criminal justice system -- that her psychic abilities can give them the upper hand when it comes to solving violent and horrifying crimes whose mysteries often reside with those who live beyond the grave. Murders and information on certain people or things come to her dreams or visions in cryptic forms and never really mean what they seem to as Allison soon discovers throughout the series. Her daughters, Bridget and Ariel Dubois, appear to have inherited their mother's gift since their 'visions' or 'dreams' usually occur when their mother is in a bind in searching for answers to her own dreams. Bridget (the second youngest child) never appears to be bothered by this, while Ariel usually has a harder time trying to cope with a gift she knows very little about. Allison is occasionally accompanied by local Arizona cop, and friend to Manuel Devalos, Det. Lee Scanlon (David Cubitt), who, at first, also did not believe that she had a "gift" upon finding out about it. Allison often bends the rules of the law when she is determined to stop a vision from happening. It is revealed later on in season two that Allison could see the dead and has been having visions since she was a child.